Association of Diastolic Dysfunction With IR, MetS and T2DM
Association of Diastolic Dysfunction With IR, MetS and T2DM
Insulin resistance and metabolic syndrome are associated with diastolic dysfunction independently of age, blood pressure and body mass index. These data suggest that subclinical changes in myocardial diastolic function are already present before the onset of diabetes, being associated mainly with the state of insulin resistance and not only to sustained hyperglycemia. Future research will determine if improving insulin resistance using insulin-sensitizers or lifestyle changes can improve diastolic function.
Conclusion
Insulin resistance and metabolic syndrome are associated with diastolic dysfunction independently of age, blood pressure and body mass index. These data suggest that subclinical changes in myocardial diastolic function are already present before the onset of diabetes, being associated mainly with the state of insulin resistance and not only to sustained hyperglycemia. Future research will determine if improving insulin resistance using insulin-sensitizers or lifestyle changes can improve diastolic function.
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