Long-term Outcome in Patients With ACS and Dysglycaemia
Long-term Outcome in Patients With ACS and Dysglycaemia
Included in the study were 1062 consecutive patients, 281 women and 781 men, aged 32–80 years, admitted to the coronary care unit at Danderyd Hospital for myocardial infarction or unstable angina between January 19, 2006 and December 29, 2008. All patients, except patients with known type 1 or type 2 diabetes, underwent a standardised 75-g OGTT according to WHO criteria at 4–5 days after admission. According to the American Diabetes Association document from 1997, the criteria for IFG were a fasting plasma glucose level of ≥6.1 to <7.0 mmol/l and a 2-h plasma glucose level at OGTT <7.8 mmol/l; and for IGT, a fasting plasma glucose level <6.1 mmol/l and a 2-h plasma glucose level at OGTT of ≥7.8 to <11.1 mmol/l. T2DM was defined as having a fasting plasma glucose value ≥7.0 mmol/l, and/or a 2-h plasma glucose value at OGTT ≥11.1 mmol/l.
Myocardial infarction and unstable angina pectoris were defined according to the criteria recommended by the Joint European Society of Cardiology and the American College of Cardiology Committee.
Data were collected in two steps:
Data are presented as mean ± standard deviation (SD) or in percentage when categorical values. The Kruskal–Wallis test followed by Mann–Whitney's U test (Table 1) or Chi square test (Table 1, Table 2, Table 3 and Table 4) was performed to analyse differences in continuous variables between groups. Data shows absolute risks. Statistical significance was set at p < 0.05. Data processing was performed using IBM SPSS, version 22.
All participants received written and oral information regarding the study and gave their written informed consent. The study protocol was approved by the local Ethics Committee at Karolinska Institutet.
Methods
Patients
Included in the study were 1062 consecutive patients, 281 women and 781 men, aged 32–80 years, admitted to the coronary care unit at Danderyd Hospital for myocardial infarction or unstable angina between January 19, 2006 and December 29, 2008. All patients, except patients with known type 1 or type 2 diabetes, underwent a standardised 75-g OGTT according to WHO criteria at 4–5 days after admission. According to the American Diabetes Association document from 1997, the criteria for IFG were a fasting plasma glucose level of ≥6.1 to <7.0 mmol/l and a 2-h plasma glucose level at OGTT <7.8 mmol/l; and for IGT, a fasting plasma glucose level <6.1 mmol/l and a 2-h plasma glucose level at OGTT of ≥7.8 to <11.1 mmol/l. T2DM was defined as having a fasting plasma glucose value ≥7.0 mmol/l, and/or a 2-h plasma glucose value at OGTT ≥11.1 mmol/l.
Myocardial infarction and unstable angina pectoris were defined according to the criteria recommended by the Joint European Society of Cardiology and the American College of Cardiology Committee.
Protocol
Data were collected in two steps:
Baseline data and OGTT results were collected at the time of admission from 2006 to 2008.
Retrospective review of the Swedish Web system for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated According to Recommended Therapies Registry (SWEDEHEART) and the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) was performed in 2012.
Statistical Analysis
Data are presented as mean ± standard deviation (SD) or in percentage when categorical values. The Kruskal–Wallis test followed by Mann–Whitney's U test (Table 1) or Chi square test (Table 1, Table 2, Table 3 and Table 4) was performed to analyse differences in continuous variables between groups. Data shows absolute risks. Statistical significance was set at p < 0.05. Data processing was performed using IBM SPSS, version 22.
Ethical Considerations
All participants received written and oral information regarding the study and gave their written informed consent. The study protocol was approved by the local Ethics Committee at Karolinska Institutet.
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