What Are Bile Acid Sequestrants?
Updated June 08, 2015.
Bile acid resins, also known as bile sequestrants or BARs, are a class of cholesterol lowering medications that work by binding to and preventing the absorption of cholesterol from the small intestine. Instead of being absorbed into the blood, the combination of cholesterol and drug is excreted through the feces. Bile acid sequestrants mainly lower LDL cholesterol (“bad” cholesterol) by 15 to 30% and only slightly raise HDL cholesterol (“good” cholesterol) by 3 to 5%.
These drugs do not appear to affect triglyceride levels and, in some cases, bile acid sequestrants may actually raise your triglycerides if taken for a long period of time.
Currently, there are three bile acid sequestrants available in the United States:
WelChol (colesevelam) is available as a tablet, Colestid (colestipol) is available as a resin (powder) or tablet, and Questran (cholestyramine) is available in the form of a resin or a wafer. Bile acid resins may be taken alone or with other cholesterol-lowering drugs in order to effectively manage your cholesterol.
Depending on the type of bile acid resin taken, some individuals may find it difficult to be consistent with taking their medication. For instance, some individuals might find the resins to be too gritty to taste. Although there are ways to improve the taste of the resins, some individuals still cannot tolerate the taste of them. While some of the bile acid resins are available in a tablet form, these tablet forms of bile acid resins may be relatively large and could be difficult to swallow.
Side effects consist of mainly gastrointestinal problems, such as flatulence, bloating, constipation, nausea, and bloating. The side effects can be managed by increasing fluid intake or by adding fiber to your diet. Additionally, bile acid resins may interact with some vitamins or other medications you are taking.
Sources:
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (PDF), July 2004, The National Institutes of Heath: The National Heart, Lung, and Blood Institute.
Dipiro JT, Talbert RL. Pharmacotherapy: A Pathophysiological Approach, 6th ed 2005.
Lacy CF, Armstrong LL, Goldman MP, et al. Lexicomp's Drug Information Handbook, 15th ed 2007.
Bile acid resins, also known as bile sequestrants or BARs, are a class of cholesterol lowering medications that work by binding to and preventing the absorption of cholesterol from the small intestine. Instead of being absorbed into the blood, the combination of cholesterol and drug is excreted through the feces. Bile acid sequestrants mainly lower LDL cholesterol (“bad” cholesterol) by 15 to 30% and only slightly raise HDL cholesterol (“good” cholesterol) by 3 to 5%.
These drugs do not appear to affect triglyceride levels and, in some cases, bile acid sequestrants may actually raise your triglycerides if taken for a long period of time.
Currently, there are three bile acid sequestrants available in the United States:
- Colestid (colestipol)
- WelChol (colesevelam)
- Questran (cholestyramine)
WelChol (colesevelam) is available as a tablet, Colestid (colestipol) is available as a resin (powder) or tablet, and Questran (cholestyramine) is available in the form of a resin or a wafer. Bile acid resins may be taken alone or with other cholesterol-lowering drugs in order to effectively manage your cholesterol.
Depending on the type of bile acid resin taken, some individuals may find it difficult to be consistent with taking their medication. For instance, some individuals might find the resins to be too gritty to taste. Although there are ways to improve the taste of the resins, some individuals still cannot tolerate the taste of them. While some of the bile acid resins are available in a tablet form, these tablet forms of bile acid resins may be relatively large and could be difficult to swallow.
Side effects consist of mainly gastrointestinal problems, such as flatulence, bloating, constipation, nausea, and bloating. The side effects can be managed by increasing fluid intake or by adding fiber to your diet. Additionally, bile acid resins may interact with some vitamins or other medications you are taking.
Sources:
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (PDF), July 2004, The National Institutes of Heath: The National Heart, Lung, and Blood Institute.
Dipiro JT, Talbert RL. Pharmacotherapy: A Pathophysiological Approach, 6th ed 2005.
Lacy CF, Armstrong LL, Goldman MP, et al. Lexicomp's Drug Information Handbook, 15th ed 2007.
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