Fingolimod Therapy for Multiple Sclerosis
Fingolimod Therapy for Multiple Sclerosis
The availability of oral fingolimod provides an important new option for management of MS. Modulation of S1P receptors on lymphocytes limits circulation of immune cells thought to be responsible for initiation of inflammatory damage. Fingolimod may also have direct beneficial effects on the CNS. Although the efficacy, tolerability, and safety have been demonstrated in large clinical trials, uncertainty surrounding cardiac AEs and long-term safety probably will reduce its use as first-line therapy for the near future. Ongoing studies will further define the role of fingolimod in the changing landscape of MS care.
Conclusion
The availability of oral fingolimod provides an important new option for management of MS. Modulation of S1P receptors on lymphocytes limits circulation of immune cells thought to be responsible for initiation of inflammatory damage. Fingolimod may also have direct beneficial effects on the CNS. Although the efficacy, tolerability, and safety have been demonstrated in large clinical trials, uncertainty surrounding cardiac AEs and long-term safety probably will reduce its use as first-line therapy for the near future. Ongoing studies will further define the role of fingolimod in the changing landscape of MS care.
Source...