Fatigue During Treatment for Hepatitis C Virus
Fatigue During Treatment for Hepatitis C Virus
Patients in the PILLAR and ASPIRE trials with chronic HCV infection treated with simeprevir in combination with PR experience a similar safety/tolerability profile and a higher SVR rate compared with patients treated with PR alone. For treatment-naïve patients in the PILLAR study, high SVR rates were achieved even though most patients who received simeprevir were able to limit PR treatment to only 24 weeks because they met RGT criteria. The clinical benefits associated with the addition of simeprevir arise without a significant increase in patient-reported fatigue beyond that reported in patients treated with PR alone, and for many patients is associated with shorter duration of health impairment (fatigue and health status) compared with PR.
Conclusions
Patients in the PILLAR and ASPIRE trials with chronic HCV infection treated with simeprevir in combination with PR experience a similar safety/tolerability profile and a higher SVR rate compared with patients treated with PR alone. For treatment-naïve patients in the PILLAR study, high SVR rates were achieved even though most patients who received simeprevir were able to limit PR treatment to only 24 weeks because they met RGT criteria. The clinical benefits associated with the addition of simeprevir arise without a significant increase in patient-reported fatigue beyond that reported in patients treated with PR alone, and for many patients is associated with shorter duration of health impairment (fatigue and health status) compared with PR.
Source...