Role of Sirtuins in Kidney Disease
Role of Sirtuins in Kidney Disease
SIRT1 exerts renal protective effects by reducing fibrosis, inhibiting apoptosis and inflammation, inducing autophagy and regulating blood pressure (Fig. 1). Therefore, SIRT1 may be a novel therapeutic target for kidney disease. However, in ADPKD, SIRT1 is involved in the progression of cyst formation (Fig. 1). SIRT3 may have important roles in renoprotection (Fig. 1); however, further investigation into the targets and functions of SIRT3 will aid the development of new strategies for protection against kidney disease.
(Enlarge Image)
Figure 1.
Role of SIRT1 and SIRT3 in the kidney. SIRT1 exerts renoprotective effects by reducing interstitial fibrosis, inhibiting inflammation and tubular and glomerular cell apoptosis, inducing autophagy and regulating Na-handling and blood pressure, through deaceylation or interaction with several targets proteins. However, SIRT1 may be involved in the progression of cyst formation in autosomal-dominant polycystic kidney disease (ADPKD). SIRT3 in mitochondria reduces lipotoxicity-induced inflammation by increasing both mitochondrial oxidative capacity and antioxidant gene expression in proximal tubular cells.
Conclusion
SIRT1 exerts renal protective effects by reducing fibrosis, inhibiting apoptosis and inflammation, inducing autophagy and regulating blood pressure (Fig. 1). Therefore, SIRT1 may be a novel therapeutic target for kidney disease. However, in ADPKD, SIRT1 is involved in the progression of cyst formation (Fig. 1). SIRT3 may have important roles in renoprotection (Fig. 1); however, further investigation into the targets and functions of SIRT3 will aid the development of new strategies for protection against kidney disease.
(Enlarge Image)
Figure 1.
Role of SIRT1 and SIRT3 in the kidney. SIRT1 exerts renoprotective effects by reducing interstitial fibrosis, inhibiting inflammation and tubular and glomerular cell apoptosis, inducing autophagy and regulating Na-handling and blood pressure, through deaceylation or interaction with several targets proteins. However, SIRT1 may be involved in the progression of cyst formation in autosomal-dominant polycystic kidney disease (ADPKD). SIRT3 in mitochondria reduces lipotoxicity-induced inflammation by increasing both mitochondrial oxidative capacity and antioxidant gene expression in proximal tubular cells.
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