Daptomycin Use in Infants and Children
Daptomycin Use in Infants and Children
As described previously, some of the cases of myopathy associated with daptomycin have been in patients also taking HMG-CoA reductase inhibitors, suggesting a possible additive or synergistic effect. In a study of 20 healthy adults taking 40 mg simvastatin daily, administration of daptomycin at a dose of 4 mg/kg daily for 2 weeks produced no change in simvastatin serum concentrations and no higher rate of myopathy than in patients given a placebo. However, due to the potential risk all patients receiving the combination must be closely monitored. The manufacturer recommends that when possible the HMG-CoA reductase inhibitor be temporarily discontinued until treatment with daptomycin has been completed.
Drug Interactions
As described previously, some of the cases of myopathy associated with daptomycin have been in patients also taking HMG-CoA reductase inhibitors, suggesting a possible additive or synergistic effect. In a study of 20 healthy adults taking 40 mg simvastatin daily, administration of daptomycin at a dose of 4 mg/kg daily for 2 weeks produced no change in simvastatin serum concentrations and no higher rate of myopathy than in patients given a placebo. However, due to the potential risk all patients receiving the combination must be closely monitored. The manufacturer recommends that when possible the HMG-CoA reductase inhibitor be temporarily discontinued until treatment with daptomycin has been completed.
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