Hospital Admission Surveillance for CPE
Hospital Admission Surveillance for CPE
Carbapenemase-producing Enterobacteriaceae (CPE) are of increasing prevalence worldwide, and long-term acute care hospitals (LTACHs) have been implicated in several outbreaks in the United States. This prospective study of routine screening for CPE on admission to a LTACH demonstrates a high prevalence of CPE colonization in central Virginia.
December 7, 2012; accepted February 25, 2013; electronically published June 27, 2013
Long-term acute care hospitals (LTACHs) are natural reservoirs for multidrug-resistant organisms (MDROs). Factors that make patients appropriate for LTACH admission (multiple comorbidities, presence of invasive medical devices, and prolonged acute or intensive care hospitalization) also places them at risk for colonization or infection with MDROs.
Over the past decade, infections due to Klebsiella pneumoniae carbapenemase (KPC)–producing Enterobacteriaceae and other carbapenemase-producing Enterobacteriaceae (CPE) have been increasingly reported throughout the United States and worldwide. LTACHs have been implicated in several US CPE outbreaks. While several studies have reported active screening for CPE in LTACHs during outbreaks, few have reported surveillance for CPE outside an outbreak situation.
CPE is not a reportable disease in Virginia, and the statewide prevalence is unknown. Here we report our experience with admission screening for CPE colonization at a single LTACH in central Virginia, which provides an indication of the prevalence of CPE among hospitalized patients in the region.
Abstract and Introduction
Abstract
Carbapenemase-producing Enterobacteriaceae (CPE) are of increasing prevalence worldwide, and long-term acute care hospitals (LTACHs) have been implicated in several outbreaks in the United States. This prospective study of routine screening for CPE on admission to a LTACH demonstrates a high prevalence of CPE colonization in central Virginia.
Introduction
December 7, 2012; accepted February 25, 2013; electronically published June 27, 2013
Long-term acute care hospitals (LTACHs) are natural reservoirs for multidrug-resistant organisms (MDROs). Factors that make patients appropriate for LTACH admission (multiple comorbidities, presence of invasive medical devices, and prolonged acute or intensive care hospitalization) also places them at risk for colonization or infection with MDROs.
Over the past decade, infections due to Klebsiella pneumoniae carbapenemase (KPC)–producing Enterobacteriaceae and other carbapenemase-producing Enterobacteriaceae (CPE) have been increasingly reported throughout the United States and worldwide. LTACHs have been implicated in several US CPE outbreaks. While several studies have reported active screening for CPE in LTACHs during outbreaks, few have reported surveillance for CPE outside an outbreak situation.
CPE is not a reportable disease in Virginia, and the statewide prevalence is unknown. Here we report our experience with admission screening for CPE colonization at a single LTACH in central Virginia, which provides an indication of the prevalence of CPE among hospitalized patients in the region.
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