Diabetes and Frailty. Part 1: Sarcopenia
Diabetes and Frailty. Part 1: Sarcopenia
AGEs have been hypothesised to play a role in the pathogenesis of sarcopaenia, through AGE-mediated increases in inflammation and endothelial dysfunction in the microcirculation of skeletal muscle and through cross-linking of collagen in skeletal muscle. Also it has been described that high AGE levels, such as of plasma CML, are related with low gait speed. Those with the highest quartile of plasma CML levels were at higher risk of slow walking speed compared with those in the lower three quartiles of plasma CML adjusting for age, education, cognitive function, smoking and chronic diseases.
Advanced Glycation End Products
AGEs have been hypothesised to play a role in the pathogenesis of sarcopaenia, through AGE-mediated increases in inflammation and endothelial dysfunction in the microcirculation of skeletal muscle and through cross-linking of collagen in skeletal muscle. Also it has been described that high AGE levels, such as of plasma CML, are related with low gait speed. Those with the highest quartile of plasma CML levels were at higher risk of slow walking speed compared with those in the lower three quartiles of plasma CML adjusting for age, education, cognitive function, smoking and chronic diseases.
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