Adjunctive Duloxetine and the Relief of Osteoarthritic Pain
Adjunctive Duloxetine and the Relief of Osteoarthritic Pain
Antidepressant treatments have been used to manage pain syndromes. Duloxetine received US FDA approval in 2010 for the indication of chronic musculoskeletal pain, including osteoarthritis (OA). The mechanism of action is thought to be related to the amelioration of central pain pathway dysfunction through actions at serotonin and norepinephrine transporters; thus, the mechanism of action is notably different from those of opioids and non-steroidal anti-inflammatory drugs (NSAIDs).
Abstract and Introduction
Abstract
Antidepressant treatments have been used to manage pain syndromes. Duloxetine received US FDA approval in 2010 for the indication of chronic musculoskeletal pain, including osteoarthritis (OA). The mechanism of action is thought to be related to the amelioration of central pain pathway dysfunction through actions at serotonin and norepinephrine transporters; thus, the mechanism of action is notably different from those of opioids and non-steroidal anti-inflammatory drugs (NSAIDs).
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