Management of Stable COPD
Management of Stable COPD
COPD is a preventable and progressive disease that is characterized by an increased chronic inflammatory response resulting in persistent airflow limitation. When exposed to noxious particles like tobacco smoke, an inflammatory response is initiated to release neutrophils and macrophages into the lungs and airways. This results in the release of chemical mediators like tumor necrosis factor alpha, interleukin 8, and leuko-triene B4. This inflammatory response is comple-mentary and leads to damage to the airways, pulmonary vasculature, and lung parenchyma. This state of chronic inflammation causes fibrosis due to constant repair, resulting in airflow limitation. Other processes like oxidative stress and imbalances of proteases and antiproteases may also play a role.
Pathophysiology
COPD is a preventable and progressive disease that is characterized by an increased chronic inflammatory response resulting in persistent airflow limitation. When exposed to noxious particles like tobacco smoke, an inflammatory response is initiated to release neutrophils and macrophages into the lungs and airways. This results in the release of chemical mediators like tumor necrosis factor alpha, interleukin 8, and leuko-triene B4. This inflammatory response is comple-mentary and leads to damage to the airways, pulmonary vasculature, and lung parenchyma. This state of chronic inflammation causes fibrosis due to constant repair, resulting in airflow limitation. Other processes like oxidative stress and imbalances of proteases and antiproteases may also play a role.
Source...