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Veterinary Use

• Trilostane is used to treat canines affected by Cushing's syndrome. This is a disease that most commonly affects middle-aged dogs. The most common cause of Cushings syndrome in canines is pituitary dependent hyperadrenocorticism. Usually about a month will lapse after starting a Trilostane regiment before a canine's body will start responding to the medication. Side effects are rare but may include: weakness, vomiting, diarrhea and lethargy.
  
  

Uses

• Cushing's syndrome is a condition that causes the adrenal gland to overproduce steroids. Steroids are very important for various parts of the body to function properly but too much steroids can cause problems. Before it was taken off the market, Trilostane was used to reduce the amount of steroids made by the adrenal gland in humans. This medication is still effective and used for the same reasons in canines.
  
  

Side Effects

• Taking Trilostane is proven to result in unwanted, adverse side effects which is why it should never be used in humans. Some common side effects associated with Trilostane use were: stomach pain, cramps, diarrhea, achy muscles, bloating, dizziness, fever, flushing, nausea, headache and watery eyes. In rare cases, some patients experienced darkening of the skin, drowsiness, loss of appetite, depression, vomiting or skin rashes. Treatment for canines resulted in reductions of cortisol and aldosterone. Use also commonly results in polydypsia, polyuria, panting, polyphagia, improved skin conditions and coat quality.
  
  

Warnings

• This medication should not be taken by people. Animals that are known to have allergic reactions to Trilostane should not take it also. This medication is no longer recommended for pregnant individuals as it has been known to cause serious problems to the body and is closely linked to the likelihood of miscarriage.
  
  

Dosing

• Proper dosages can be different among different breeds of canines. The proper dosing schedule for a patient should be determined by a trained veterinarian. Response to therapy will usually take around a month.