How to Treat Antisperm Antibodies

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    Instructions

    • 1). Schedule a blood- or semen-analysis test to identify, confirm and quantify the presence of the antibodies. Seek your doctor's advice as to whether you should take the Immunobead Assay or Immunobead Binding Test (IBT), the Mixed Agglutination Reaction (MAR) Test or the Antisperm Antibody AB Test. These tests use antibodies that are attached to small markers---such as red blood cells or plastic beads---that naturally attach to sperm cells that contain antibodies on their surface. The results of the test will reflect the percentage of sperm cells bound by antibodies. The IBT counts the number of antisperm antibodies in your semen or blood. On the other hand, the MAR is exclusively for a semen sample. The Antisperm Antibody AB test is essential in finding out whether actual antibodies are present on the sperm cell itself and not in the circulating blood. The presence of both IgA and IgG antisperm antibodies are measured and detected on the surface of sperm.

    • 2). Consult your physician about using high doses of corticosteroids to reduce the number of antibodies. Corticosteroids are also believed to deliver the sperm directly into both the uterus and the fallopian tubes so that they can bypass the cervical mucus that may contain the antibodies.

    • 3). Ask your doctor about using assisted reproductive techniques like intrauterine insemination (IUI). This involves the insertion of specially prepared sperm into the uterus during ovulation. This technique is considered effective for couples whose problem involves the cervical mucus containing antibodies. IUI is also less complex and cheaper than other methods.

    • 4). Consider using in vitro fertilization (IVF), as this method is said to be the most effective in countering antisperm antibodies. It is considered effective especially in cases where antibodies are bound to almost 100 percent of sperm cells.

    • 5). Consider combining IVF with intracytoplasmic sperm injection (ICSI), which involves the direct fertilization of an egg by a single sperm in order to treat antibodies and is usually the choice if there is still no fertilization after one attempt at using IVF.

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