MRI Changes in Schizophrenia
MRI Changes in Schizophrenia
This is the Medscape Psychiatry Minute. I am Dr. Peter Yellowlees. It is well established that schizophrenia is associated with structural brain abnormalities, but whether these are static or progress over time remains controversial. Now a team of investigators from the University of Edinburgh, Scotland, have performed a systematic review of 27 longitudinal, volumetric structural MRI studies in 928 patients with schizophrenia and 867 healthy control patients, focusing on 32 different brain regions of interest. They found that patients with schizophrenia showed significantly greater decreases over time than controls in whole-brain volume, whole-brain gray matter, frontal gray and white matter, parietal white matter, and temporal white matter volume, as well as larger increases in lateral ventricular volume. These findings confirm that schizophrenia is associated with progressive structural brain abnormalities affecting both gray and white matter. Our next test is to uncover the causes and clinical correlates of these progressive brain changes. This article is selected from Medscape Best Evidence. I am Dr. Peter Yellowlees.
Abstract
This is the Medscape Psychiatry Minute. I am Dr. Peter Yellowlees. It is well established that schizophrenia is associated with structural brain abnormalities, but whether these are static or progress over time remains controversial. Now a team of investigators from the University of Edinburgh, Scotland, have performed a systematic review of 27 longitudinal, volumetric structural MRI studies in 928 patients with schizophrenia and 867 healthy control patients, focusing on 32 different brain regions of interest. They found that patients with schizophrenia showed significantly greater decreases over time than controls in whole-brain volume, whole-brain gray matter, frontal gray and white matter, parietal white matter, and temporal white matter volume, as well as larger increases in lateral ventricular volume. These findings confirm that schizophrenia is associated with progressive structural brain abnormalities affecting both gray and white matter. Our next test is to uncover the causes and clinical correlates of these progressive brain changes. This article is selected from Medscape Best Evidence. I am Dr. Peter Yellowlees.
Abstract
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