Selective Serotonin Reuptake Inhibitors (SSRIs)

• Selective serotonin reuptake inhibitors, also known as SSRIs, are commonly prescribed for depression. The role of SSRIs is to block reuptake of serotonin by certain nerve cells in the brain. This means that more serotonin is left in the brain to enhance nerve impulses and improve mood. Some examples of prescribed medications are Celexa, Lexapro, Prozac, Paxil, Pexeva and Zoloft.
  
  

Tricyclic Antidepressants (TCAs)

• Tricyclic antidepressants (TCAs) inhibit the reuptake of all three neurotransmitters associated with mood. These neurotransmitters are serotonin, norepinephrine and dopamine. They all remain longer in the brain, elevating mood. Examples of TCAs are Elavil, Norpramin, Tofranil, Aventyl and Pamelor.
  
  

Monamine Oxidase Inhibitors (MAOIs)

• Monamine oxidase inhibitors (MAOIs) are less commonly used to treat depression, because they have many side effects. These medications work by preventing the enzyme monoamine oxidase from metabolizing the neurotransmitters norepinephrine, serotonin and dopamine. This means that they remain in the brain and elevate mood. Examples of MAOIs are Marplan, Nardil and Parnate.
  
  

Norepinephrine and Dopamine Reuptake Inhibitors (NDRIs)

• Norepinephrine and dopamine reuptake inhibitors (NDRIs) work by inhibiting the reuptake of dopamine and norepinephrine in the brain. This causes them to remain in the brain longer and promote a healthy mood. An example of an NDRI is Wellbutrin.
  
  

Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)

• Serotonin and norepinephrine reuptake inhibitors (SNRIs) function by inhibiting the reuptake of serotonin and norepinephrine. These chemicals stay longer in the brain, and their increased levels positively affect mood and behavior. Examples of SNRIs are Effexor and Cymbalta.