Function

• Nortriptyline works by increasing levels of the neurotransmitters norepinephrine and serotonin, while blocking acetylcholine.
  
  

Side Effects

• Common side effects include dry mouth, constipation, change in appetite and drowsiness.
  
  

Dosage

• Normal dosage for adults is 25 mg three to four times daily. In elderly patients, dosage should be divided up to a maximum dosage of 30 to 50 mg per day.
  
  

Warning

• Per the FDA, any patient with major depression disorder may experience worsening symptoms of depression until significant remission occurs.
  
  

History

• Nortriptyline was approved by the FDA in November 1964 under the brand name Aventyl Hydrocholride.