IgG4-Related Kidney Disease
IgG4-Related Kidney Disease
Although several mechanisms including autoimmunity, allergy, or innate immunity have been discussed, the role of IgG4 in IgG4-RD and the pathogenesis of IgG4-RD is poorly understood. Predominance of a Th2-cell response and activation of regulatory T cells at affected sites have been commonly confirmed in various organs in association with IgG4-RD; production of IL-4, IL-10, and TGF-β is also markedly increased in IgG4-TIN compared with other types of TIN. Accumulation of cases and further examinations will be required to clarify the pathogenesis of IgG4-RKD.
Pathogenesis
Although several mechanisms including autoimmunity, allergy, or innate immunity have been discussed, the role of IgG4 in IgG4-RD and the pathogenesis of IgG4-RD is poorly understood. Predominance of a Th2-cell response and activation of regulatory T cells at affected sites have been commonly confirmed in various organs in association with IgG4-RD; production of IL-4, IL-10, and TGF-β is also markedly increased in IgG4-TIN compared with other types of TIN. Accumulation of cases and further examinations will be required to clarify the pathogenesis of IgG4-RKD.
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