First Reports of Adverse Drug Reactions
First Reports of Adverse Drug Reactions
The following table contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks. Any claim to a 'first report' is verified by a database search of previous literature.
Serious = an event when the patient outcome is death, life-threatening, hospitalisation, disability, congenital anomaly, or requires intervention to prevent permanent impairment or damage (FDA MedWatch definition).
The following table contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks. Any claim to a 'first report' is verified by a database search of previous literature.
| Drug and ADR | Reference |
|---|---|
| Amifostine: Stevens-Johnson syndrome and toxic epidermal necrolysis (serious) | Atahan IL, Özyar E, Sahin S, et al. Two cases of Stevens-Johnson syndrome: toxic epidermal necrolysis possibly induced by amifostine during radiotherapy. Br J Dermatol 2000 Nov; 143: 1072-3 |
| Amiodarone: absence status (serious) | Papageorgiou S, Giannakodimos S, Dali P, et al. Absence status associated with amiodarone intoxication [abstract]. Eur J Neurol 2000 Nov; 7 Suppl. 3: 38 |
| Azithromycin/erythromycin/spiramycin: serum sickness (serious) | Navarro JA, Villas F, García JC, et al. Macrolide-induced serum sickness [abstract]. Allergy & Clinical Immunology International 2000 Suppl. 2: 158 |
| Buspirone: interaction with concomitant ritonavir leading to parkinsonism | Clay PG, Adams MM. Severe pseudoparkinsonism secondary to a ritonavir-buspirone interaction [abstract]. Clin Infect Dis 2000 Jul; 31: 257 |
| Disopyramide: interaction with concomitant azithromycin leading to ventricular tachycardia (serious) | Granowitz EV, Tabor KJ, Kirchhoffer JB. Potentially fatal interaction between azithromycin and disopyramide. Pacing Clin Electrophysiol 2000 Sep; 23: 1433-5 |
| Infliximab: poor wound healing (serious) | Griffin SP, Selby WS. Poor wound healing following surgery in three patients who received infliximab for Crohn's disease [abstract]. J Gastroenterol Hepatol 2000 Oct; 15 Suppl.: 78 |
| Methadone: interaction with concomitant ciprofloxacin leading to drowsiness, confusion and respiratory depression (serious) | Herrlin K, Segerdahl M, Gustafsson LL, et al. Methadone, ciprofloxacin, and adverse drug reactions. Lancet 2000 Dec 16; 356: 2069-70 |
| Moxifloxacin: tachycardia | Siepmann M, Kirch W. Tachycardia associated with moxifloxacin. BMJ 2001 Jan 6; 322: 23 |
| Oxaliplatin: muscle necrosis following extravasation (serious) | Baur M, Kienzer H-R, Rath T, et al. Extravasation of oxaliplatin (Eloxatin) - clinical course. Onkologie 2000 Oct; 23: 468-71 |
| Reboxetine: spontaneous and premature ejaculation | O'Flynn R, Michael A. Reboxetine-induced spontaneous ejaculation. Br J Psychiatry 2000 Dec; 177: 567-8 |
Serious = an event when the patient outcome is death, life-threatening, hospitalisation, disability, congenital anomaly, or requires intervention to prevent permanent impairment or damage (FDA MedWatch definition).
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