CSF Biomarkers in Parkinsonian Conditions: An Update
CSF Biomarkers in Parkinsonian Conditions: An Update
We reviewed the potential use of CSF proteins as biomarkers in parkinsonism, focusing on α-Syn, neuronal injury markers and Aβ42. In addition, we briefly reviewed the latest novel markers and the 'omics' approach. We performed a PubMed/Medline search and limited searches to studies reported in English and published after 2006, including antemortem, human, lumbar CSF; all studies included at least one parkinsonian cohort compared with healthy or neurological controls. We combined searches with 'Parkinson's disease', 'progressive supranuclear palsy', 'multiple system atrophy', 'corticobasal syndrome' (CBS), 'corticobasal degeneration', 'Parkinson's disease dementia', 'dementia with Lewy bodies', 'Lewy body dementia', 'parkinsonism', 'synucleinopathies', 'tauopathies', 'neurodegenerative diseases' with 'CSF biomarkers' and specific biomarkers ('α-Syn', 'tau', 'phosphorylated tau', 'Aβ42', 'neurofilaments', 'neuronal injury markers', 'inflammatory', 'metabolic' and 'oxidative stress markers'). Further references were found manually from identified publications. For a review of the earlier literature, not captured using the time limit of our search criteria, see Eller and Williams.
Methods
We reviewed the potential use of CSF proteins as biomarkers in parkinsonism, focusing on α-Syn, neuronal injury markers and Aβ42. In addition, we briefly reviewed the latest novel markers and the 'omics' approach. We performed a PubMed/Medline search and limited searches to studies reported in English and published after 2006, including antemortem, human, lumbar CSF; all studies included at least one parkinsonian cohort compared with healthy or neurological controls. We combined searches with 'Parkinson's disease', 'progressive supranuclear palsy', 'multiple system atrophy', 'corticobasal syndrome' (CBS), 'corticobasal degeneration', 'Parkinson's disease dementia', 'dementia with Lewy bodies', 'Lewy body dementia', 'parkinsonism', 'synucleinopathies', 'tauopathies', 'neurodegenerative diseases' with 'CSF biomarkers' and specific biomarkers ('α-Syn', 'tau', 'phosphorylated tau', 'Aβ42', 'neurofilaments', 'neuronal injury markers', 'inflammatory', 'metabolic' and 'oxidative stress markers'). Further references were found manually from identified publications. For a review of the earlier literature, not captured using the time limit of our search criteria, see Eller and Williams.
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