2,000 Years of Changing Perspectives on Malaria
2,000 Years of Changing Perspectives on Malaria
Between 1885 and 1892, Bartolomeo Camillo Golgi studied the asexual cycle of the malaria parasite and related its stages to the observed stages of the various forms of malaria (Figure 8). He found that the febrile bouts coincided with segmentation ("Golgi's law"). His work was the first to demonstrate the concept of a biological clock.
(Enlarge Image)
Figure 8.
Golgi's original microphotograph of a daisy-like malaria blood preparation. (Courtesy Museum for the History of the University of Pavia).
In studying the relationship between the biological cycle of the malarial parasite and the onset of fever, Golgi found that the two types of intermittent malarial fevers (tertian, occurring every other day, and quartan, occurring every third day) were caused by different species of Plasmodium and that the paroxysms of fever coincided with the rupture and release of merozoites into the bloodstream.
Camillo Golgi
Between 1885 and 1892, Bartolomeo Camillo Golgi studied the asexual cycle of the malaria parasite and related its stages to the observed stages of the various forms of malaria (Figure 8). He found that the febrile bouts coincided with segmentation ("Golgi's law"). His work was the first to demonstrate the concept of a biological clock.
(Enlarge Image)
Figure 8.
Golgi's original microphotograph of a daisy-like malaria blood preparation. (Courtesy Museum for the History of the University of Pavia).
In studying the relationship between the biological cycle of the malarial parasite and the onset of fever, Golgi found that the two types of intermittent malarial fevers (tertian, occurring every other day, and quartan, occurring every third day) were caused by different species of Plasmodium and that the paroxysms of fever coincided with the rupture and release of merozoites into the bloodstream.
Source...