Dermatopathology of Rheumatologic Diseases
Dermatopathology of Rheumatologic Diseases
Granulomatous vasculitis is used to describe both granulomatous inflammation that is angiocentric, and granulomatous inflammation not associated with vessels with neutrophilic, necrotizing vasculitis, also called 'vasculitis with granulomatosis'. Vasculitis with granulomatosis is seen in Wegener granulomatosis (Figures 22–24) or Churg–Strauss syndrome (Figures 25–27).
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Figure 22.
Wegener granulomatosis with dermal inflammatory infiltrates (hematoxylin and eosin 2×).
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Figure 23.
Wegener granulomatosis with angiocentric and granulomatous inflammation (hematoxylin and eosin 10×).
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Figure 24.
Wegener granulomatosis with angiocentric and granulomatous inflammation seen at higher magnification (hematoxylin and eosin 40×).
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Figure 25.
Churg–Strauss syndrome with dense dermal inflammation (hematoxylin and eosin 2×).
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Figure 26.
Churg–Strauss syndrome, a granulomatous vasculitis with angiocentric granulomatous inflammation associated with vessels with neutrophilic, necrotizing vasculitis (hematoxylin and eosin 20×).
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Figure 27.
Churg–Strauss syndrome, a granulomatous vasculitis with angiocentric granulomatous inflammation associated with vessels with neutrophilic, necrotizing vasculitis at a higher magnification (hematoxylin and eosin 40×).
Rare cases of postherpetic eruptions, sarcoidosis, metastatic Crohn disease, ulcerative colitis, connective tissue disease vasculitis, hepatitis C infection, and ANCA-associated vasculitis with a granulomatous vasculitis are reported.
Granulomatous Vasculitis
Granulomatous vasculitis is used to describe both granulomatous inflammation that is angiocentric, and granulomatous inflammation not associated with vessels with neutrophilic, necrotizing vasculitis, also called 'vasculitis with granulomatosis'. Vasculitis with granulomatosis is seen in Wegener granulomatosis (Figures 22–24) or Churg–Strauss syndrome (Figures 25–27).
(Enlarge Image)
Figure 22.
Wegener granulomatosis with dermal inflammatory infiltrates (hematoxylin and eosin 2×).
(Enlarge Image)
Figure 23.
Wegener granulomatosis with angiocentric and granulomatous inflammation (hematoxylin and eosin 10×).
(Enlarge Image)
Figure 24.
Wegener granulomatosis with angiocentric and granulomatous inflammation seen at higher magnification (hematoxylin and eosin 40×).
(Enlarge Image)
Figure 25.
Churg–Strauss syndrome with dense dermal inflammation (hematoxylin and eosin 2×).
(Enlarge Image)
Figure 26.
Churg–Strauss syndrome, a granulomatous vasculitis with angiocentric granulomatous inflammation associated with vessels with neutrophilic, necrotizing vasculitis (hematoxylin and eosin 20×).
(Enlarge Image)
Figure 27.
Churg–Strauss syndrome, a granulomatous vasculitis with angiocentric granulomatous inflammation associated with vessels with neutrophilic, necrotizing vasculitis at a higher magnification (hematoxylin and eosin 40×).
Rare cases of postherpetic eruptions, sarcoidosis, metastatic Crohn disease, ulcerative colitis, connective tissue disease vasculitis, hepatitis C infection, and ANCA-associated vasculitis with a granulomatous vasculitis are reported.
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