Diabetes, Insulin Use, and Helicobacter Pylori Eradication
Diabetes, Insulin Use, and Helicobacter Pylori Eradication
Table 1 compares the baseline characteristics between diabetic and non-diabetic subjects. The diabetic patients were older and female predominant, and had higher prevalence rates of comorbidities, medication use and PES (in 2005 or 1997–2005).
The annual incidences of HP eradication in different groups are shown in Table 2. HP eradication rates increased with increasing age, and were higher in men, diabetic patients and insulin users. Significant differences were also seen for occupation and living region.
The mutually-adjusted odds ratios for HP eradication are shown in Table 3. For all subjects, age, male sex, diabetes, PES (1997–2005), hypertension, chronic obstructive pulmonary disease, stroke, nephropathy, ischemic heart disease, peripheral arterial disease, dyslipidemia, calcium channel blocker, living region (northern and central) and occupation (III and IV) were significantly associated with a higher incidence. Except for dyslipidemia and living region in northern Taiwan, the significant variables for the diabetic patients only were all the same as in the model for all subjects. Furthermore, insulin use was significantly associated with HP eradication.
The unadjusted and adjusted odds ratios for HP eradication for diabetes status (for all subjects), diabetes duration (for all subjects) and insulin use (for diabetic patients only) are shown in Table 4. Diabetes was associated with a significantly higher odds ratio of HP eradication in all models, though the odds ratio attenuated when more covariates were adjusted, especially when the comorbidities were considered (models III and IV). The odds ratios attenuated with increasing diabetes duration and with adjustment for covariates, especially when comorbidities and medications were included. The odds ratios became insignificant for diabetes duration of more than 3 years in models III and IV. Insulin use was significantly associated with a higher odds ratio though the magnitude of the odds ratios attenuated slightly after adjustment for covariates.
Results
Table 1 compares the baseline characteristics between diabetic and non-diabetic subjects. The diabetic patients were older and female predominant, and had higher prevalence rates of comorbidities, medication use and PES (in 2005 or 1997–2005).
The annual incidences of HP eradication in different groups are shown in Table 2. HP eradication rates increased with increasing age, and were higher in men, diabetic patients and insulin users. Significant differences were also seen for occupation and living region.
The mutually-adjusted odds ratios for HP eradication are shown in Table 3. For all subjects, age, male sex, diabetes, PES (1997–2005), hypertension, chronic obstructive pulmonary disease, stroke, nephropathy, ischemic heart disease, peripheral arterial disease, dyslipidemia, calcium channel blocker, living region (northern and central) and occupation (III and IV) were significantly associated with a higher incidence. Except for dyslipidemia and living region in northern Taiwan, the significant variables for the diabetic patients only were all the same as in the model for all subjects. Furthermore, insulin use was significantly associated with HP eradication.
The unadjusted and adjusted odds ratios for HP eradication for diabetes status (for all subjects), diabetes duration (for all subjects) and insulin use (for diabetic patients only) are shown in Table 4. Diabetes was associated with a significantly higher odds ratio of HP eradication in all models, though the odds ratio attenuated when more covariates were adjusted, especially when the comorbidities were considered (models III and IV). The odds ratios attenuated with increasing diabetes duration and with adjustment for covariates, especially when comorbidities and medications were included. The odds ratios became insignificant for diabetes duration of more than 3 years in models III and IV. Insulin use was significantly associated with a higher odds ratio though the magnitude of the odds ratios attenuated slightly after adjustment for covariates.
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