Causes

• Gout is caused by crystal deposits in the joints and too much uric acid in the body when the kidneys don't remove it. Consuming alcohol and shellfish may increase uric acid.
  
  

Those Affected

• Three million Americans have gout. It affects more men than women, women after menopause and those with kidney disease. Gout is also associated with diabetes, high blood pressure and obesity.
  
  

Symptoms

• Symptoms of gout come on quickly, usually at night and without warning. The affected areas will become red, swollen and tender. Gout usually affects the big toe but can occur in hands and wrists, knees, ankles and feet.
  
  

Treatment

• Gout is treated with the anti-inflammatory drug colchicine and non-steroidal anti-inflammatory drugs naproxen and indomethacin. Some patients are treated with steroidal anti-inflammatory drugs called corticosteroids.
  
  

Side Effects

• Side effects of naproxen and indomethacin include diarrhea, ulcers and stomach irritation. Colchicine can cause diarrhea, nausea and vomiting, but may not have side effects when taken in lower doses.